PcimOlki pisze:honda11 pisze:PcimOlki pisze:honda11 pisze:...Moja wetka postawiła na Ampicilinę. ...
Jak długo planuje ją podawać?
Nie rozmawiałyśmy jeszcze o tym, bo ona będzie w lecznicy dopiero w poniedziałek.
Z moich, ulotnych już, zapamiętanych informacji wynika
wrażenie, że Ampicylina nie jest dobrym wyborem przy UTI. Być może właśnie z powodu szybkiego przystosowywania się E.C. do niej. W ogólności literatura wskazuje fluorochinolony jako antybiotyki pierwszego rzutu przy UTI. Stąd wybór Ampiciliny wydaje mi się wątpliwy - może jutro doczytam co napisano w mądrych książkach i przyjrzę sie jeszcze wynikom, szczególnie o leczeniu OZN, które jest wyjątkowo upierdliwe.....
http://www.jurology.com/article/S0022-5 ... 2/abstractAlthough some geographic variation is noted in resistance rates among urinary tract Escherichia coli isolates, rates were highest for ampicillin (39% to 45%) and trimethoprim-sulfamethoxazole (14% to 31.4%) and lowest for nitrofurantoin (1.8% to 16%) and fluoroquinolones (0.7% to 10%)
Veterinary Medicine International Volume 2011 (2011), Article ID 263768
http://www.hindawi.com/journals/vmi/2011/263768/Fragmenty:
Table 1: Summary of first-line antimicrobial options for UTIs in the dog and cat.Infection Type First-line drug optionsUncomplicated UTI - Amoxicillin, trimethoprim-sulfonamide
Complicated - Guided by culture and susceptibility testing, but consider amoxicillin or trimethoprim-sulfonamide initially
Subclinical bacteriuria - Antimicrobial therapy not recommended unless high risk for ascending infection. If so, treat as per complicated UTI
Pyelonephritis - Start with a fluoroquinolone, with re-assessment based on culture and susceptibility testing
Table 2: Antimicrobial treatment options for urinary tract infections in the dog and cat.Amoxicillin - Good first-line option for UTIs. Excreted in urine predominantly in active form if normal renal function is present.
Ineffective against beta-lactamase-producing bacteria....
Ampicillin - Not recommended because of poor oral bioavailability. Amoxicillin is preferred.
....
Cephalexin, Cefadroxil - Enterococci are resistant. Resistance may be common in Enterobacteriaceae in some regions.
...
Cefovecin - Should only be used in situations where oral treatment is problematic. Enterococci are resistant. Pharmacokinetic data are available to support the use in dogs and cats, with a duration of 14 days (dogs) and 21 days (cats). The long duration of excretion in the urine makes it difficult to interpret posttreatment culture results.
...
Ciprofloxacin - Sometimes used because of lower cost than enrofloxacin. Lower and more variable oral bioavailability than enrofloxacin, marbofloxacin, and orbifloxacin. Difficult to justify over approved fluoroquinolones. Dosing recommendations are empirical.
...
Enrofloxacin - Excreted in urine predominantly in active form. Reserve for documented resistant UTIs but good
First-line choice for pyelonephritis (20 mg/kg PO q24h). Limited efficacy against enterococci.
Associated with risk of retinopathy in cats. Do not exceed 5 mg/kg/d of enrofloxacin in cats....
Marbofloxacin - Excreted in urine predominantly in active form. Reserve for documented resistant UTIs but
good First-line choice for pyelonephritis. Limited efficacy against enterococci.
...
Nitrofurantoin - Good second-line option for simple uncomplicated UTI, particularly when multidrug-resistant pathogens are involved.